Professional Education | Topic Of Interest

Pine Rest Grand Rounds

“A Cannabinoid Hypothesis of Schizophrenia: Pathways to Psychosis”


Observations regarding drug-induced psychotic states led to the dopamine, serotonin, and glutamate hypotheses of schizophrenia. Expanding knowledge about the endocannabinoid system and the impact of exogenous Phyto cannabinoids on the brain and behavior have revealed several putative pathways to cannabis-induced psychosis. The presentation describes these pathways, proposes a cannabinoid hypothesis of schizophrenia and discusses targeted therapeutic interventions.


  1. Examine the Epidemiology of Cannabis Use and its Relationship to Psychosis
  2. Review the Neurobiology of the Endocannabinoid System
  3. Illuminate the Pathways to Cannabis-Induced Psychosis
  4. Examine Strategies for Managing Cannabis Use and Preventing Psychosis Relapse


  • Dale D’Mello MD

    Dr. Dale DeMello’s work on the adult inpatient psychiatry unit at Sparrow Hospital and in the Navigate Early Psychosis Program in Lansing has increased his awareness of the role of cannabis in the precipitation and perpetuation of psychotic symptoms.
  • Rachel Little

    Rachel Little is a science communicator based in Lansing, Michigan that is focused on disseminating current scientific research to the general population.
Skip to content